Flushing, urticaria, and nausea are symptoms of what type of contrast agent reaction?

• A. Local irritation
• B. Cardiovascular shock
• C. Anaphylactic shock
• D. Psychogenic shock

Answer: (C)

These symptoms show a systemic immediate hypersensitivity reaction to iodinated contrast media. Flushing and urticaria arise from histamine release, causing widespread skin vasodilation and increased vessel permeability. Nausea often accompanies these reactions as part of the same immune-driven response. Taken together, they point to an anaphylactic-type reaction to the contrast, which can escalate to anaphylactic shock if not treated promptly with measures like epinephrine and airway support.

Local irritation would be confined to the injection area, not producing widespread flushing and hives. Psychogenic shock isn’t driven by the contrast reaction, and cardiovascular shock describes a late, more advanced state rather than the initial signs.